Article
Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms.
The American journal of pathology - 1 Feb 1999
Görtz B, Roth J, Krähenmann A, de Krijger R R, Muletta-Feurer S, Rütimann K, Saremaslani P, Speel E J, Heitz P U, Komminoth P
Abstract excerpt
Endocrine pancreatic tumors (EPT) and neuroendocrine tumors (NET) occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). We analyzed the frequency of allelic deletions and mutations of the recently identified MEN1 gene in 53 sporadic tumors including 30 EPT and 23 NET (carcinoids) of different locations and types. Allelic deletion of the MEN1 locus was identified in 18/49...
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