Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors.

doi:10.1210/jcem.86.3.7332

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Article

Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors.

The Journal of clinical endocrinology and metabolism - 1 Mar 2001

Hessman O, Skogseid B, Westin G, Akerström G

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome with multiple tumors of the endocrine pancreas, the parathyroid, the pituitary, and other tissues. The MEN1 gene at 11q13 is homozygously mutated in the majority of MEN1 tumors. Here we present a genome-wide loss of heterozygosity (LOH) screening of 23 pancreatic lesions, one duodenal tumor, and one thymic carcinoid from 13 MEN1 patients....

Topics

Adult
Aged
Alleles
Carcinoid Tumor
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 6
Duodenal Neoplasms
Gene Deletion
Genetic Markers
Humans
Loss of Heterozygosity
Middle Aged
Multiple Endocrine Neoplasia Type 1
Pancreatic Neoplasms
Thymus Neoplasms

Source

Open in PubMed

Identifiers

PMID: 11238532
DOI: 10.1210/jcem.86.3.7332

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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