Article
Stimulated rapid expression in vitro for early detection of in vivo T-cell receptor mutations induced by radiation exposure.
Mutation research - 23 May 1997
Ishioka N, Umeki S, Hirai Y, Akiyama M, Kodama T, Ohama K, Kyoizumi S
Abstract excerpt
The T-cell receptor (TCR) mutation assay for in vivo somatic mutations is a sensitive indicator of exposure to ionizing radiation. However, this assay cannot be immediately applied after radiation exposure because expression of a mutant phenotype may require as long as several months. In the pres...
Topics
- Antigens, Differentiation, T-Lymphocyte
- CD4-Positive T-Lymphocytes
- Cell Division
- Cells, Cultured
- Dose-Response Relationship, Radiation
- Female
- Flow Cytometry
- Gene Expression
- Humans
- Interleukin-2
- Lymphocyte Activation