Article
Stimulated rapid expression in vitro for early detection of in vivo T-cell receptor mutations induced by radiation exposure.
Mutation research - 23 May 1997
Ishioka N, Umeki S, Hirai Y, Akiyama M, Kodama T, Ohama K, Kyoizumi S
Abstract excerpt
The T-cell receptor (TCR) mutation assay for in vivo somatic mutations is a sensitive indicator of exposure to ionizing radiation. However, this assay cannot be immediately applied after radiation exposure because expression of a mutant phenotype may require as long as several months. In the present study, we eliminate this time lag by stimulating lymphocytes with a mitogen that can accelerate the turnover of TCR...
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