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Article

Measurement of mutant frequency in T-cell receptor (TCR) gene by flow cytometry after X-irradiation on EL-4 mice lymphoma cells.

The Journal of toxicological sciences - 1 Oct 2007

Kunugita Naoki, Mei Nan, Goncharova Tatjana, Norimura Toshiyuki

Abstract excerpt

It is well known that somatic mutations are induced by ionizing irradiation. We have previously reported the measurement of mutant frequency (MF) on the T-cell receptor (TCR) gene in mouse T-lymphocytes after irradiation by flow cytometry. In this study, we developed an in vitro system using murine EL-4 lymphoma cells and observed frequency of cells defective in TCR gene expression after exposure to ionizing...

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Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Hypoxanthine Phosphoribosyltransferase

Share to Micronucleus Tests

Share to Receptors, Antigen, T-Cell

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Source

Identifiers

PMID: 17965552
DOI: 10.2131/jts.32.377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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