Article
Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to X-rays.
Mutation research - 10 Jan 2011
Varès Guillaume, Wang Bing, Tanaka Kaoru, Kakimoto Ayana, Eguchi-Kasai Kyomi, Nenoi Mitsuru
Abstract excerpt
The ability of cells to adapt low-dose or low-dose rate radiation is well known. High-LET radiation has unique characteristics, and the data concerning low doses effects and high-LET radiation remain fragmented. In this study, we assessed in vitro the ability of low doses of X-rays to induce an adaptive response (AR) to a subsequent challenging dose of heavy-ion radiation. Lymphoblastoid cells (TK6, AHH-1, NH32)...
Topics
- Adaptation, Physiological
- Apoptosis
- Cell Cycle
- Cell Line
- Dose-Response Relationship, Radiation
- Histones
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Kinetics
- Linear Energy Transfer
- Lymphocytes