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Article

Development of a mouse model for studying in vivo T-cell receptor mutations.

Mutation research - 18 Sept 1997

Umeki S, Suzuki T, Kusunoki Y, Seyama T, Fujita S, Kyoizumi S

Abstract excerpt

An experimental system was established to study in vivo T-cell receptor alpha beta (TCR) mutations in murine CD4+ T-lymphocytes. The frequency of TCR-defective mutant T-cells that have the CD3-4+ surface phenotype, was measured using two-color flow cytometry of splenic T-cells passed through nylon wool. The spontaneous TCR mutant frequency (MF) in BALB/c mice (2.3 x 10(-4)) was significantly lower than the...

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PMID: 9357560
DOI: 10.1016/s1383-5718(97)00084-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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