Article
Development of a mouse model for studying in vivo T-cell receptor mutations.
Mutation research - 18 Sept 1997
Umeki S, Suzuki T, Kusunoki Y, Seyama T, Fujita S, Kyoizumi S
Abstract excerpt
An experimental system was established to study in vivo T-cell receptor alpha beta (TCR) mutations in murine CD4+ T-lymphocytes. The frequency of TCR-defective mutant T-cells that have the CD3-4+ surface phenotype, was measured using two-color flow cytometry of splenic T-cells passed through nylo...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Dose-Response Relationship, Radiation
- Female
- Humans
- Kinetics
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Models, Genetic
- Mutagenesis
- Mutagenicity Tests
- Mutation
- Receptors, Antigen, T-Cell, alpha-beta
- Species Specificity
- X-Rays