Article
Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP (HTLV-I-associated myelopathy/tropical spastic paraparesis).
Journal of neuroimmunology - 1 Jun 1997
Yamano Y, Kitze B, Yashiki S, Usuku K, Fujiyoshi T, Kaminagayoshi T, Unoki K, Izumo S, Osame M, Sonoda S
Abstract excerpt
To determine CD4+ T-cell epitopes of HTLV-I-envelope protein recognized by the HLA alleles associated with HAM/TSP, we established 20 CD4+ T-cell lines from peripheral blood mononuclear cells (PBMCs) of naive healthy donors using a panel of synthetic peptides spanning the entire length of HTLV-I-...
Topics
- Alleles
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- Cell Line
- Gene Products, env
- Genes, MHC Class II
- HLA-DR Antigens
- HLA-DRB1 Chains
- Hematopoietic Stem Cells
- Humans
- Molecular Sequence Data
- Paraparesis, Tropical Spastic
- Retroviridae Proteins, Oncogenic