Article
Identification of HLA-A24 restricted pre-erythrocytic stage specific T-cell epitopes using Plasmodium falciparum synthetic peptides: a preliminary study.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 2009
Tippawangkosol Pongsri, Duangchanda Thitimonrat, Ubalee Ratawan, Ruengweerayut Ronnatrai, Hirayama Kenji, Na-Bangchang Kesara
Abstract excerpt
Fourteen (9 amino acids) peptides of Plasmodium falciparum pre-erythrocytic stage antigens, namely, TRAP, CTRP, LSA-1, STARP and MSP-1, restricted to HLA-A24 and specific to T-cell response were identified. The antigen-specific IFN-gamma responses of these synthetic peptides in malaria exposed and non-malaria exposed healthy adult volunteers were detected using the ex vivo ELISPOT assay. Five peptides from TRAP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.