Article
HLA-A*24 Increases the Risk of HTLV-1-Associated Myelopathy despite Reducing HTLV-1 Proviral Load.
International journal of molecular sciences - 22 Jun 2024
Tanaka Masakazu, Takenouchi Norihiro, Arishima Shiho, Matsuzaki Toshio, Nozuma Satoshi, Matsuura Eiji, Takashima Hiroshi, Kubota Ryuji
Abstract excerpt
Increased human T-cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is a significant risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is controversy surrounding whether HTLV-1-specific cytotoxic T lymphocytes (CTLs) are beneficial or harmful to HAM/TSP patients. Recently, HTLV-1 Tax 301-309 has been identified as an immunodominant epitope restricted to HLA-A*2402....
Topics
- HLA-A Antigens
- Risk Factors
- Human T-lymphotropic virus 1
- Paraparesis, Tropical Spastic
- Viral Load
- Alleles
- T-Lymphocytes, Cytotoxic
- Gene Products, tax
- Epitopes, T-Lymphocyte
- Computer Simulation
- Humans
- Gene Frequency