Article
Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4+ TEM Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in "Humanized" HLA-DR Transgenic Mice.
Journal of virology - 17 Mar 2020
Srivastava Ruchi, Coulon Pierre-Gregoire A, Prakash Swayam, Dhanushkodi Nisha R, Roy Soumyabrata, Nguyen Angela M, Alomari Nuha I, Mai Uyen T, Amezquita Cassendra, Ye Caitlin, Maillère Bernard, BenMohamed Lbachir
Abstract excerpt
While the role of CD8+ T cells in the control of herpes simplex virus 1 (HSV-1) infection and disease is gaining wider acceptance, a direct involvement of effector CD4+ T cells in this protection and the phenotype and function of HSV-specific human CD4+ T cell epitopes remain to be fully elucidated. In the present study, we report that several epitopes from the HSV-1 virion tegument protein (VP11/12) encoded by...
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