Article
Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals.
Virology journal - 6 Mar 2013
Mota-Miranda Aline C A, Barreto Fernanda K, Amarante Maria F C, Batista Everton, Monteiro-Cunha Joana P, Farre Lourdes, Galvão-Castro Bernardo, Alcantara Luiz C J
Abstract excerpt
BACKGROUND: Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiological agent of tropical spastic paraparesis/HTLV-associated myelopathy (HAM/TSP) that can be identified in around 0.25%-3.8% of the infected population. Disease progression can be monitored by the proviral load and may depend on genetic factors, however, it is not well understood why some HTLV-1 infected people develop the disease while others...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Carrier State
- Epitopes, T-Lymphocyte
- Female
- Gene Products, env
- Human T-lymphotropic virus 1
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation