Article
Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.
Science (New York, N.Y.) - 13 Jun 1997
Posas F, Saito H
Abstract excerpt
Exposure of the yeast Saccharomyces cerevisiae to high extracellular osmolarity induces the Sln1p-Ypd1p-Ssk1p two-component osmosensor to activate a mitogen-activated protein (MAP) kinase cascade composed of the Ssk2p and Ssk22p MAP kinase kinase kinases (MAPKKKs), the Pbs2p MAPKK, and the Hog1p MAPK. A second osmosensor, Sho1p, also activated Pbs2p and Hog1p, but did so through the Ste11p MAPKKK. Although Ste11p...
Topics
- Calcium-Calmodulin-Dependent Protein Kinases
- Enzyme Activation
- Genes, Fungal
- Genetic Complementation Test
- MAP Kinase Kinase Kinases
- Mating Factor
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Mutation
- Osmolar Concentration