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Article

A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway.

The EMBO journal - 15 Jul 2003

Tatebayashi Kazuo, Takekawa Mutsuhiro, Saito Haruo

Abstract excerpt

Mitogen-activated protein kinase (MAPK) cascades are conserved signaling modules composed of three sequentially activated kinases (MAPKKK, MAPKK and MAPK). Because individual cells contain multiple MAPK cascades, mechanisms are required to ensure the fidelity of signal transmission. In yeast, external high osmolarity activates the HOG (high osmolarity glycerol) MAPK pathway, which consists of two upstream...

Topics

Amino Acid Sequence
Cell Nucleus
Enzyme Activation
Fungal Proteins
Intracellular Signaling Peptides and Proteins
MAP Kinase Kinase Kinases
MAP Kinase Signaling System
Membrane Proteins
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Molecular Sequence Data

Mutation

Osmotic Pressure

Protein Binding

Protein Kinases

Protein Serine-Threonine Kinases

Protein Structure, Tertiary

Source

Open in PubMed Open full text

Identifiers

PMID: 12853477
DOI: 10.1093/emboj/cdg353
PMCID: PMC165623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12853477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway.PMID 12853477Read ↗

Evidence that the MAPK-docking site in MAPKK Dpbs2p is essential for its function.Semantic proximity Read ↗

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.Semantic proximity Read ↗

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.Semantic proximity Read ↗

Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator.Semantic proximity Read ↗

Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway.Semantic proximity Read ↗

A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.Semantic proximity Read ↗

Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.Semantic proximity Read ↗

Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.Semantic proximity Read ↗

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.Semantic proximity Read ↗

Ssk1p-independent activation of Ssk2p plays an important role in the osmotic stress response in Saccharomyces cerevisiae: alternative activation of Ssk2p in osmotic stress.Semantic proximity Read ↗

MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans.Semantic proximity Read ↗

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