Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

doi:10.1126/science.7624781

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Article

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

Science (New York, N.Y.) - 28 Jul 1995

Maeda T, Takekawa M, Saito H

Abstract excerpt

The role of mitogen-activated protein (MAP) kinase cascades in integrating distinct upstream signals was studied in yeast. Mutants that were not able to activate PBS2 MAP kinase kinase (MAPKK; Pbs2p) at high osmolarity were characterized. Pbs2p was activated by two independent signals that emanat...

Topics

Amino Acid Sequence
Calcium-Calmodulin-Dependent Protein Kinases
Cloning, Molecular
Enzyme Activation
Fungal Proteins
Genes, Fungal
Intracellular Signaling Peptides and Proteins
MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Molecular Sequence Data
Mutation
Osmolar Concentration
Phosphorylation
Protein Kinases
Protein Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 7624781
DOI: 10.1126/science.7624781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7624781-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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