Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator.

Abstract excerpt

Exposure of yeast cells to increased extracellular osmolarity induces the HOG1 mitogen-activated protein kinase (MAPK) cascade, which is composed of SSK2, SSK22 and STE11 MAPKKKs, PBS2 MAPKK and HOG1 MAPK. The SSK2/SSK22 MAPKKKs are activated by a 'two-component' osmosensor composed of SLN1, YPD1 and SSK1. The SSK1 C-terminal receiver domain interacts with an N-terminal segment of SSK2. Upon hyperosmotic...

Topics

• Amino Acid Sequence
• Calcium-Calmodulin-Dependent Protein Kinases
• Enzyme Activation
• Fungal Proteins
• Intracellular Signaling Peptides and Proteins
• MAP Kinase Kinase Kinases
• Mitogen-Activated Protein Kinases
• Molecular Sequence Data
• Mutation
• Osmotic Pressure