Article
A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.
Molecular biology of the cell - 1 Nov 2007
Cheetham Jill, Smith Deborah A, da Silva Dantas Alessandra, Doris Kathryn S, Patterson Miranda J, Bruce Catherine R, Quinn Janet
Abstract excerpt
The Hog1 mitogen-activated protein kinase (MAPK) plays a central role in stress responses in the human pathogen Candida albicans. Here, we have investigated the MAPK kinase kinase (MAPKKK)-dependent regulation of the pathway. In contrast to the Hog1 pathway in Saccharomyces cerevisiae, which is r...
Topics
- Candida albicans
- Gene Deletion
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Mutation
- Phenotype
- Phosphorylation
- Protein Binding