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Article

A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.

Molecular biology of the cell - 1 Nov 2007

Cheetham Jill, Smith Deborah A, da Silva Dantas Alessandra, Doris Kathryn S, Patterson Miranda J, Bruce Catherine R, Quinn Janet

Abstract excerpt

The Hog1 mitogen-activated protein kinase (MAPK) plays a central role in stress responses in the human pathogen Candida albicans. Here, we have investigated the MAPK kinase kinase (MAPKKK)-dependent regulation of the pathway. In contrast to the Hog1 pathway in Saccharomyces cerevisiae, which is regulated by three MAPKKKs (Ssk2, Ssk22, and Ste11), our results demonstrate that Hog1 in C. albicans is regulated by a...

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Identifiers

PMID: 17804815
DOI: 10.1091/mbc.e07-06-0581
PMCID: PMC2043575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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