Article
Differential effects of cytolytic T cell subsets on intracellular infection.
Science (New York, N.Y.) - 13 Jun 1997
Stenger S, Mazzaccaro R J, Uyemura K, Cho S, Barnes P F, Rosat J P, Sette A, Brenner M B, Porcelli S A, Bloom B R, Modlin R L
Abstract excerpt
In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4(-)CD8(-) (double-negative) T cells and CD8(+) T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4(-)CD8(-) T cells was mediated by Fas-FasL interaction and had no effect on the viability of the...
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