Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection.

Cell death & disease - 19 May 2016

Cabral-Piccin M P, Guillermo L V C, Vellozo N S, Filardy A A, Pereira-Marques S T, Rigoni T S, Pereira-Manfro W F, DosReis G A, Lopes M F

Abstract excerpt

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi. CD8 T-lymphocytes help to control infection, but apoptosis of CD8 T cells disrupts immunity and efferocytosis can enhance parasite infection within macrophages. Here, we investigate how apoptosis of activated CD8 T cells affects M1 and M2 macrophage phenotypes. First, we found that CD8 T-lymphocytes and inflammatory monocytes/macrophages...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Cell Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chagas Disease

Share to Fas Ligand Protein

Share to Host-Parasite Interactions

Share to Immunity, Cellular

Share to Lectins, C-Type

Share to Trypanosoma cruzi

Source

Open in PubMed Open full text

Identifiers

PMID: 27195678
DOI: 10.1038/cddis.2016.135
PMCID: PMC4917666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection.PMID 27195678Read ↗

Mechanisms regulating host cell death during Leishmania infectionSemantic proximity Read ↗

Management of cell death in parasitic infectionsSemantic proximity Read ↗

Leishmaniasis: Immune Cells Crosstalk in Macrophage PolarizationSemantic proximity Read ↗

Effect of Apoptotic Cell Recognition on Macrophage Polarization and Mycobacterial PersistenceSemantic proximity Read ↗

Leishmaniasis: Immune Cells Crosstalk in Macrophage PolarizationSemantic proximity Read ↗

Living on the Edge: Inhibition of Host Cell Apoptosis by <i>Mycobacterium Tuberculosis</i>Semantic proximity Read ↗

Macrophage Apoptosis in TuberculosisSemantic proximity Read ↗

Toxoplasma gondiiModulates the Host Cell Responses: An Overview of Apoptosis PathwaysSemantic proximity Read ↗

Pathological roles of macrophages in Leishmania infectionsSemantic proximity Read ↗

<i>Leishmania amazonensis</i> controls macrophage-regulated cell death to establish chronic infection <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?Semantic proximity Read ↗

In the Acute Phase of Trypanosoma cruzi Infection, Liver Lymphoid and Myeloid Cells Display an Ambiguous Phenotype Combining Pro- and Anti-Inflammatory Markers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.