Article
Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans.
Blood - 1 Apr 2000
Yasukawa M, Ohminami H, Arai J, Kasahara Y, Ishida Y, Fujita S
Abstract excerpt
We investigated the cytotoxicity mechanisms of alloantigen-specific human CD4(+) and CD8(+) cytotoxic T lymphocytes (CTLs) using cells from family members with the Fas gene mutation. Alloantigen-specific CD4(+) and CD8(+) CTL bulk lines and clones were generated from 2 individuals by stimulation of their peripheral blood lymphocytes with allogeneic Fas(-/-) or Fas(+/-) cell lines that were established from...
Topics
- Anti-Bacterial Agents
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Line
- Cytoplasmic Granules
- Cytotoxicity, Immunologic
- Egtazic Acid
- Exocytosis
- Fas Ligand Protein
- Granzymes
- Humans
- Isoantigens
- Macrolides