Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD8- and CD95/95L-Dependent Mechanisms of Resistance in Mice with Chronic Pulmonary Tuberculosis

1 Feb 2001

Abstract excerpt

The role of CD8 T lymphocytes in the immune response to Mycobacterium tuberculosis infection remains enigmatic, with persuasive reports of both cytolytic and noncytolytic (cytokine-mediated) responses to infection. To address the importance of the cytolytic mechanisms, mice with targeted disruptions for CD8 and perforin or with gene mutations in the CD95/ CD95L signaling pathway were exposed to pulmonary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11159055
DOI: 10.1165/ajrcmb.24.2.4370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD8- and CD95/95L-Dependent Mechanisms of Resistance in Mice with Chronic Pulmonary TuberculosisPMID 11159055Read ↗

CD95 signaling is not required for the down regulation of cellular responses to systemic Mycobacterium tuberculosis infection.Semantic proximity Read ↗

FasL regulatory B-cells during Mycobacterium tuberculosis infection and TB diseaseSemantic proximity Read ↗

Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.Semantic proximity Read ↗

The protective immune response to Mycobacterium tuberculosisSemantic proximity Read ↗

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restrictedSemantic proximity Read ↗

A Novel Nonclassic β 2-Microglobulin–Restricted Mechanism Influencing Early Lymphocyte Accumulation and Subsequent Resistance to Tuberculosis in the LungSemantic proximity Read ↗

Type I IFN signaling triggers immunopathology in tuberculosis‐susceptible mice by modulating lung phagocyte dynamicsSemantic proximity Read ↗

B7 costimulation is critical for host control of chronic Mycobacterium tuberculosis infection.Semantic proximity Read ↗

CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.Semantic proximity Read ↗

Bcells and their regulatory functions during Tuberculosis: Latency and active diseaseSemantic proximity Read ↗

Contribution of CD8+ T Cells to Control of <i>Mycobacterium tuberculosis</i> InfectionSemantic proximity Read ↗

Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.