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Article

The human macrophage cell line U937 as an <i>in vitro</i> model for selective evaluation of mycobacterial antigen‐specific cytotoxic T‐cell function

1 Feb 2001

Abstract excerpt

Despite strong evidence for CD8+ T-cell function in murine mycobacterial infections, their corresponding role in human tuberculosis has proven more difficult to demonstrate. We have evaluated the human macrophage (Mphi) cell line U937 as an in vitro model for human leucocyte antigen (HLA) class I-restricted presentation of mycobacterial antigens, as HLA class I is constitutively expressed at high levels by U937...

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Identifiers

PMID: 11260319
DOI: 10.1046/j.1365-2567.2001.01164.x

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