Article
Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression.
Journal of cellular biochemistry - 15 Jun 1997
Lee J S, Scala S, Matsumoto Y, Dickstein B, Robey R, Zhan Z, Altenberg G, Bates S E
Abstract excerpt
MCF-7 human breast cancer cells selected in Adriamycin in the presence of verapamil developed a multidrug resistant phenotype, which was characterized by as much as 100,000-fold resistance to mitoxantrone, 667-fold resistance to daunorubicin, and 600-fold resistance to doxorubicin. Immunoblot and...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Antibiotics, Antineoplastic
- Antigens, Neoplasm
- Breast Neoplasms
- Cell Division
- Cloning, Molecular
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Daunorubicin
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Female