Article
ATP-dependent transport of lipophilic cytotoxic drugs by membrane vesicles prepared from MRP-overexpressing HL60/ADR cells.
Biochemistry - 5 Nov 1996
Paul S, Breuninger L M, Kruh G D
Abstract excerpt
MRP is an ATP-binding cassette family transporter that confers cellular resistance to a variety of natural product cytotoxic agents. However, the biochemical mechanism by which MRP confers resistance has not been established. To gain insight into its mechanism of action, the in vitro substrate sp...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Antineoplastic Agents
- Biological Transport, Active
- Cell Membrane
- Daunorubicin
- Drug Resistance, Multiple
- Glutathione
- HL-60 Cells
- Humans
- Kinetics
- Multidrug Resistance-Associated Proteins
- Osmotic Pressure
- Phenotype