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Article

The efflux of anthracyclines in multidrug-resistant cell lines.

Biochemical pharmacology - 19 Oct 1993

Coley H M, Twentyman P R, Workman P

Abstract excerpt

In order to address the association of enhanced drug efflux with the multidrug-resistant (MDR) phenotype, we have studied the cellular pharmacokinetics of anthracyclines in the P-glycoprotein (Pgp)-positive MDR cell lines H69/LX4 (human small cell lung cancer) and EMT6/AR1.0 (mouse mammary tumour). Both doxorubicin (DOX) and daunorubicin (DNR) were accumulated to a lesser extent and effluxed at a higher rate by...

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Identifiers

PMID: 7902089
DOI: 10.1016/0006-2952(93)90094-d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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