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Article

The efflux of anthracyclines in multidrug-resistant cell lines.

Biochemical pharmacology - 19 Oct 1993

Coley H M, Twentyman P R, Workman P

Abstract excerpt

In order to address the association of enhanced drug efflux with the multidrug-resistant (MDR) phenotype, we have studied the cellular pharmacokinetics of anthracyclines in the P-glycoprotein (Pgp)-positive MDR cell lines H69/LX4 (human small cell lung cancer) and EMT6/AR1.0 (mouse mammary tumour). Both doxorubicin (DOX) and daunorubicin (DNR) were accumulated to a lesser extent and effluxed at a higher rate by...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Aclarubicin
Animals
Anthracyclines
Antibiotics, Antineoplastic
Carrier Proteins
Cyclosporine
Daunorubicin
Doxorubicin
Drug Resistance
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Mice

Phenotype

Tumor Cells, Cultured

Verapamil

Source

Identifiers

PMID: 7902089
DOI: 10.1016/0006-2952(93)90094-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7902089-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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