Article
Biochemical and pharmacological characterization of MCF-7 drug-sensitive and AdrR multidrug-resistant human breast tumor xenografts in athymic nude mice.
Biochemical pharmacology - 5 Jul 1991
Mimnaugh E G, Fairchild C R, Fruehauf J P, Sinha B K
Abstract excerpt
The phenotypic expression of multidrug resistance by the doxorubicin-selected AdrR human breast tumor cell line is associated with overexpression of plasma membrane P-170 glycoprotein and increased cytosolic selenium-dependent GSH-peroxidase activity relative to the parental MCF-7 wild-type line...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- Breast Neoplasms
- Cell Line
- Cytochrome P-450 Enzyme System
- Doxorubicin
- Drug Resistance
- Drug Tolerance
- Electron Spin Resonance Spectroscopy
- Glutathione
- Humans
- Hydroxides
- Hydroxyl Radical
- Membrane Glycoproteins
- Mice
- Mice, Nude
- Neoplasm Transplantation