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Article

Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues.

Analytical biochemistry - 1 May 1997

Keohavong P, Zhu D, Whiteside T L, Swalsky P, Bakker A, Elder E M, Siegfried J M, Srivastava S, Finkelstein S D

Abstract excerpt

A sensitive method was developed and applied to examine the distribution of K-ras gene mutations in histologically differing areas of lung tissues obtained from lung cancer patients. This method, which combines polymerase chain reaction (PCR), mutation allele enrichment (MAE), and denaturing gradient gel electrophoresis (DGGE), allows detection of one K-ras mutant allele present in 10(4) to 10(5) wild-type...

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Identifiers

PMID: 9177704
DOI: 10.1006/abio.1997.2100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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