Suppression of UV-induced mutations by wild-type p53 protein in human osteosarcoma cells.

doi:10.1093/mutage/12.3.191

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Article

Suppression of UV-induced mutations by wild-type p53 protein in human osteosarcoma cells.

Mutagenesis - 1 May 1997

Yamagishi N, Miyakoshi J, Yagi T, Takebe H

Abstract excerpt

We have examined whether the tumour suppressor p53 protein suppressed UV-induced mutations in the hypoxathine-guanine phosphoribosyl transferase (HPRT) gene and in the supF gene of the shuttle vector plasmid pMY189. We used human osteosarcoma Saos-LP12 cells, in which wild type (wt) p53 protein w...

Topics

Base Sequence
DNA Repair
Genetic Vectors
Humans
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data
Mutation
Osteosarcoma
Plasmids
Suppression, Genetic
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Ultraviolet Rays

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