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Article

Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells.

Carcinogenesis - 1 Apr 1997

Yamagishi N, Miyakoshi J, Takebe H

Abstract excerpt

Tumor suppressor p53 protein acts as a checkpoint factor following DNA damage. Inactivation of checkpoint control may increase the frequency of mutation following DNA damage, resulting in tumor progression. Here we examine whether wild-type (wt) p53 protein suppresses X-ray-induced mutations using an isopropyl-beta-D-thiogalactopyranoside (IPTG)-regulated p53 expression system in human osteosarcoma Saos-2 cells....

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Source

Identifiers

PMID: 9111202
DOI: 10.1093/carcin/18.4.695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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