Article
Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells.
Carcinogenesis - 1 Apr 1997
Yamagishi N, Miyakoshi J, Takebe H
Abstract excerpt
Tumor suppressor p53 protein acts as a checkpoint factor following DNA damage. Inactivation of checkpoint control may increase the frequency of mutation following DNA damage, resulting in tumor progression. Here we examine whether wild-type (wt) p53 protein suppresses X-ray-induced mutations usin...
Topics
- Apoptosis
- Cell Cycle
- Cell Division
- Clone Cells
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutation
- Osteosarcoma
- Tumor Suppressor Protein p53
- X-Rays