Article
High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture.
Neuroreport - 24 Mar 1997
Farhangrazi Z S, Ying H, Bu G, Dugan L L, Fagan A M, Choi D W, Holtzman D M
Abstract excerpt
A hallmark of Alzheimer's disease (AD) is the extracellular deposition and accumulation of a 39-43 amino peptide, known as the amyloid beta (A beta) protein, within the brain. It has been postulated that A beta may in some way contribute directly to AD pathogenesis. The epsilon 4 allele of apolipoprotein E (apoE) is a major AD risk factor. Since both apoE and A beta are components of lipoproteins in plasma and...
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