Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of A beta 42 in Alzheimer's disease.

Journal of physiology, Paris - 1 Jan 2000

Younkin S G

Abstract excerpt

Our recent studies of plasma, fibroblasts, transfected cells and transgenic mice show that a fundamental effect of the mutations linked to familial Alzheimer's disease (FAD) is to increase the extracellular concentration of A beta 42. This effect of the FAD-linked mutations is likely to be direct...

Topics

Age of Onset
Alzheimer Disease
Amyloid beta-Peptides
Animals
Clinical Trials as Topic
Humans
Mutation
Peptide Fragments

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9789825
DOI: 10.1016/s0928-4257(98)80035-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9789825-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of A beta 42 in Alzheimer's disease.PMID 9789825Read ↗

Presenilins and Alzheimer's disease: the role of A beta 42.Semantic proximity Read ↗

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.Semantic proximity Read ↗

Abeta42, presenilins, and Alzheimer's disease.Semantic proximity Read ↗

[The AAP and PS1/2 mutations linked to early onset familial Alzheimer's disease increase the extracellular concentration and A beta 1-42 (43)].Semantic proximity Read ↗

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.Semantic proximity Read ↗

APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain.Semantic proximity Read ↗

Plasma and Cerebrospinal Fluid Levels of Amyloid β Proteins 1-40 and 1-42 in Alzheimer DiseaseSemantic proximity Read ↗

Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease.Semantic proximity Read ↗

Intracellular biology of Alzheimer's disease amyloid beta peptide.Semantic proximity Read ↗

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.Semantic proximity Read ↗

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.Semantic proximity Read ↗

Increased cerebrospinal fluid A beta38/A beta42 ratio in Alzheimer disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.