Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death.

Brain research - 22 Feb 2010

Bruinsma Ilona B, Wilhelmus Micha M M, Kox Matthijs, Veerhuis Robert, de Waal Robert M W, Verbeek Marcel M

Abstract excerpt

Cerebral amyloid angiopathy (CAA) is a common pathological finding in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis of the Dutch type; in this latter condition it is caused by deposition of mutated amyloid beta protein (Abeta Glu22Gln; D-Abeta(1-40)). Previously, we foun...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Apolipoprotein E3
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Astrocytes

Share to Cell Death

Share to Cerebral Amyloid Angiopathy

Share to Culture Media, Conditioned

Share to Pericytes

Source

Identifiers

PMID: 20034483
DOI: 10.1016/j.brainres.2009.12.039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20034483-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death.PMID 20034483Read ↗

Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.Semantic proximity Read ↗

Apolipoprotein E genotype regulates amyloid-beta cytotoxicity.Semantic proximity Read ↗

Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β ProteinSemantic proximity Read ↗

Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer's disease.Semantic proximity Read ↗

Astrocytic Synapse Engulfment Is Differentially Controlled by <i>APOE</i> GenotypeSemantic proximity Read ↗

ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane ComponentsSemantic proximity Read ↗

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated PathwaySemantic proximity Read ↗

Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.Semantic proximity Read ↗

Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of PericytesSemantic proximity Read ↗

APOE genotype-dependent modulation of astrocyte chemokine CCL3 production.Semantic proximity Read ↗

The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of beta-amyloid angiopathy (CAA).Semantic proximity Read ↗

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.