Article
Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.
Annals of the New York Academy of Sciences - 1 Apr 2000
Verbeek M M, Van Nostrand W E, Otte-Höller I, Wesseling P, De Waal R M
Abstract excerpt
Amyloid-beta (A beta) deposition in cerebral vessels (cerebral amyloid angiopathy, CAA) is accompanied by degeneration of vascular cells, including pericytes and smooth muscle cells. Previous studies indicated that specific A beta protein isoforms are toxic for cultured human brain pericytes and smooth muscle cells. In particular, A beta 1-40 carrying the E22Q mutation, as in hereditary cerebral hemorrhage with...
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