Characterization of a thermosensitive Escherichia coli aspartyl-tRNA synthetase mutant.

doi:10.1128/jb.179.11.3691-3696.1997

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Article

Characterization of a thermosensitive Escherichia coli aspartyl-tRNA synthetase mutant.

Journal of bacteriology - 1 Jun 1997

Martin F, Sharples G J, Lloyd R G, Eiler S, Moras D, Gangloff J, Eriani G

Abstract excerpt

The Escherichia coli tls-1 strain carrying a mutated aspS gene (coding for aspartyl-tRNA synthetase), which causes a temperature-sensitive growth phenotype, was cloned by PCR, sequenced, and shown to contain a single mutation resulting in substitution by serine of the highly conserved proline 555...

Topics

Aspartate-tRNA Ligase
Escherichia coli
Models, Molecular
Mutation
Structure-Activity Relationship
Temperature

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