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Article

Influence of tRNA tertiary structure and stability on aminoacylation by yeast aspartyl-tRNA synthetase.

Nucleic acids research - 11 Jan 1993

Puglisi J D, Pütz J, Florentz C, Giegé R

Abstract excerpt

Mutations have been designed that disrupt the tertiary structure of yeast tRNA(Asp). The effects of these mutations on both tRNA structure and specific aspartylation by yeast aspartyl-tRNA synthetase were assayed. Mutations that disrupt tertiary interactions involving the D-stem or D-loop result in destabilization of the base-pairing in the D-stem, as monitored by nuclease digestion and chemical modification...

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Identifiers

PMID: 8441619
DOI: 10.1093/nar/21.1.41
PMCID: PMC309063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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