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Article

A non-discriminating aspartyl-tRNA synthetase from Halobacterium salinarum.

RNA biology - 1 Jul 2006

Cardoso Alexander Machado, Polycarpo Carla, Martins Orlando Bonifácio, Söll Dieter

Abstract excerpt

The tRNA-dependent transamidation pathway is the essential route for Asn-tRNA(Asn) formation in organisms that lack an asparaginyl-tRNA synthetase. This pathway relies on a nondiscriminating aspartyl-tRNA synthetase (ND-AspRS encoded by aspS), an enzyme with relaxed tRNA specificity, to form Asp-tRNA(Asn). The misacylated tRNA is then converted to Asn-tRNA(Asn) by the action of an Asp-tRNA(Asn) amidotransferase....

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Source

Identifiers

PMID: 17114946
DOI: 10.4161/rna.3.3.3116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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