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Article

Location of a mutation in the aspartyl-tRNA synthetase gene of Escherichia coli K12.

Mutation research - 1 Nov 1991

Sharples G J, Lloyd R G

Abstract excerpt

A mutation (tls-1) that confers a temperature-sensitive growth phenotype in Escherichia coli was shown by DNA cloning and sequencing to be an allele of aspS, the gene for aspartyl-tRNA synthetase. The mutation, which lies near minute 41 on the genetic map, was located some 2.3 kb from the 5' end of the ruvAB operon. A DNA fragment encoding the carboxy-terminus of AspRS was found to be sufficient to allow growth...

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PMID: 1944398
DOI: 10.1016/0165-7992(91)90122-k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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