A rapid, specific, and sensitive method for the determination of acetylation phenotype using dapsone.

doi:10.1093/jat/21.3.203

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Article

A rapid, specific, and sensitive method for the determination of acetylation phenotype using dapsone.

Journal of analytical toxicology - 1 Jan 2000

Queiroz R H, Dreossi S A, Carvalho D

Abstract excerpt

An original, simple, specific, and rapid high-performance liquid chromatography assay for the determination of dapsone and monoacetyldapsone in human plasma is presented. The procedure consists of extracting the drugs and the internal standard (phenacetin) from 1 mL plasma with ethyl ether at alk...

Topics

Acetylation
Anti-Infective Agents
Calibration
Chromatography, High Pressure Liquid
Dapsone
Ether
Humans
Hydrogen-Ion Concentration
Phenacetin
Phenotype
Reference Standards
Reproducibility of Results
Sensitivity and Specificity
Time Factors

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