Article
Acetylation polymorphism and leprosy.
Biochemical genetics - 1 Feb 1990
Eze L C, Okpogba A N, Ogan A U
Abstract excerpt
The sulfones are the drug of choice in the treatment of leprosy, with dapsone as the clear favorite. The major route for dapsone metabolism leading to its inactivation and excretion is via acetylation by hepatic N-acetyl transferase (NAT), as is the case with isoniazid (INH) and sulfamethazine (S...
Topics
- Acetylation
- Acetyltransferases
- Humans
- Incidence
- Leprosy
- Nigeria
- Phenotype
- Polymorphism, Genetic
- Sulfamethazine