Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs.

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Article

Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 1995

Palamanda J R, Hickman D, Ward A, Sim E, Romkes-Sparks M, Unadkat J D

Abstract excerpt

Dapsone is used in the treatment of Pneumocystis carinii pneumonia, an opportunistic infection that afflicts acquired immunodeficiency syndrome (AIDS) patients. Inhibition of N-acetyltransferase (NAT)-dependent acetylation of dapsone could increase peak plasma concentrations of dapsone and shift the biotransformation pathway to the P450-mediated formation of a toxic metabolite of dapsone, the hydroxylamine....

Topics

Acetylation
Adult
Anti-Bacterial Agents
Arylamine N-Acetyltransferase
Base Sequence
Cloning, Molecular
Cytosol
Dapsone
Escherichia coli
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Kinetics

Liver

Male

Middle Aged

Molecular Sequence Data

Opportunistic Infections

Source

Open in PubMed

Identifiers

PMID: 7600914

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7600914-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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