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Article

Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 1995

Palamanda J R, Hickman D, Ward A, Sim E, Romkes-Sparks M, Unadkat J D

Abstract excerpt

Dapsone is used in the treatment of Pneumocystis carinii pneumonia, an opportunistic infection that afflicts acquired immunodeficiency syndrome (AIDS) patients. Inhibition of N-acetyltransferase (NAT)-dependent acetylation of dapsone could increase peak plasma concentrations of dapsone and shift the biotransformation pathway to the P450-mediated formation of a toxic metabolite of dapsone, the hydroxylamine....

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Source

Identifiers

PMID: 7600914

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs.PMID 7600914Read ↗

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N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism.Semantic proximity Read ↗

A rapid, specific, and sensitive method for the determination of acetylation phenotype using dapsone.Semantic proximity Read ↗

Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases.Semantic proximity Read ↗

Case Study 10: A Case to Investigate Acetyl Transferase Kinetics.Semantic proximity Read ↗

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