Human N-acetylation genotype determination with urinary caffeine metabolites.

doi:10.1038/clpt.1990.59

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Article

Human N-acetylation genotype determination with urinary caffeine metabolites.

Clinical pharmacology and therapeutics - 1 Apr 1990

Kilbane A J, Silbart L K, Manis M, Beitins I Z, Weber W W

Abstract excerpt

The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achieved by adding a phenyl column, in tande...

Topics

Acetylation
Caffeine
Chromatography, High Pressure Liquid
Gene Frequency
Genetics, Population
Genotype
Humans
Nitrogen
Pedigree
Phenotype
Theophylline
Time Factors
Uracil
Uric Acid
Xanthines

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