Article
Reassessment of dapsone as a marker of acetylator phenotypes.
International journal of clinical pharmacology, therapy, and toxicology - 1 Jul 1991
Wiggan E B, Dennis S, Reele S B, Luke D R
Abstract excerpt
The ratio of metabolite to parent dapsone concentrations at 3 hours after dosing has been used as a marker of acetylator phenotypes. The absorption of dapsone is somewhat erratic with peak concentrations often found after the 3-hour determination. The present study done in 30 healthy, male volunteers compared ratios of metabolite to parent dapsone concentrations 3 hours after dosing with AUC values calculated...
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