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Article

The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding.

Bioscience reports - 31 Jan 2020

Indurthi Venkata S K, Jensen Jaime L, Leclerc Estelle, Sinha Sangita, Colbert Christopher L, Vetter Stefan W

Abstract excerpt

The receptor for advanced glycation end products (RAGE) recognizes damage-associated molecular patterns (DAMPs) and plays a critical role for the innate immune response and sterile tissue inflammation. RAGE overexpression is associated with diabetic complications, neurodegenerative diseases and certain cancers. Yet, the molecular mechanism of ligand recognition by RAGE is insufficiently understood to rationalize...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31912881
DOI: 10.1042/BSR20193360
PMCID: PMC6997106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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