Article
5' regulatory nucleotide sequence of an HLA-A*0101null allele.
Immunogenetics - 1 Jan 1997
Lardy N M, Otting N, van der Horst A R, Bontrop R E, de Waal L P
Abstract excerpt
We have previously demonstrated an HLA-A*0101null allele segregating in a family with the HLA-B8, -Cw7, -DR3, -DR52, -DQ2 haplotype. In the present study the regulatory elements with known transcription enhancement activity of the silenced HLA-A*0101 allele were analyzed. In the enhancer B element, a T was substituted for a C at position - 106, whereas no other alterations were found in the adjacent 5' section of...
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