Article
Differential regulation of HLA class I genes by interferon.
Immunogenetics - 1 Jan 1990
Schmidt H, Gekeler V, Haas H, Engler-Blum G, Steiert I, Probst H, Müller C A
Abstract excerpt
Allele-specific differences in the regulation of HLA class I genes by type I interferon (IFN) were observed after transfection of eight HLA-B, -A, or -C genes into mouse L cells. HLA-B7 and -Bw64 gene expression was significantly more inducible by type I IFN than the genes coding for HLA-B27, HLA-B51, HLA-B38, HLA-B39, HLA-Cw3, and HLA-A2 antigens. Modification of the 5' end of HLA-B7 and HLA-B27 genes revealed...
Topics
- Alleles
- Animals
- Base Sequence
- Blotting, Northern
- Cell Line
- Chromosome Deletion
- Gene Expression Regulation
- Genes, MHC Class II
- Histocompatibility Antigens Class I
- Interferons
- L Cells