Article
Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
Immunogenetics - 1 Jan 1992
Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T
Abstract excerpt
The beta chain of the HLA-DQ molecule is shorter by eight amino acid residues than other major histocompatibility complex class II beta chains due to elimination of the fifth exon coding for part of the cytoplasmic domain. This elimination is caused by one base substitution in the splice acceptor site of the exon. We found that two HLA-DQB1 alleles, DQB1*0503 and DQB1*0601, did not have this substitution, and the...
Topics
- Alleles
- Base Sequence
- Cell Line, Transformed
- Cytoplasm
- Exons
- Gene Expression
- HLA-DQ Antigens
- Humans
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Polymerase Chain Reaction