Article
cis-acting regulatory elements abrogate allele-specific HLA class I gene expression in healthy individuals.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1992
Lardy N M, Bakas R M, van der Horst A R, van Twuyver E, Bontrop R E, de Waal L P
Abstract excerpt
Pedigree analysis of a Dutch family revealed the presence of an HLA-A "blanc" allele segregating with the HLA-B8, -Cw7, -DR3, -DR52, -DQ2 haplotype. Precipitation studies, using selected mAb and sera directed against conserved epitopes of HLA class I products, failed to detect the expression of a corresponding HLA-A locus product. cDNA nucleotide sequence analysis of the HLA-A "blanc" specificity showed that the...
Topics
- Alleles
- Base Sequence
- Cloning, Molecular
- Cytokines
- Gene Expression Regulation
- Genes, MHC Class I
- HLA-A Antigens
- Histocompatibility Antigens Class I
- Humans
- Molecular Sequence Data