Article
Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells.
Molecular cell - 26 Oct 2012
Zhang Yu, Shishkin Alexander A, Nishida Yuri, Marcinkowski-Desmond Dana, Saini Natalie, Volkov Kirill V, Mirkin Sergei M, Lobachev Kirill S
Abstract excerpt
Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger gross chromosomal rearrangements. The mechanisms that regulate the metabolism of GAA/TTC repeats are poorly...
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