Article
Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast.
Human molecular genetics - 1 Mar 1997
Schweitzer J K, Livingston D M
Abstract excerpt
To examine the genetic factors that affect the stability of disease-associated trinucleotide repeats, we have assessed the stability of CAG repeats in yeast strains with mutations in the mismatch repair system. We have found that both pms1 and msh2 mutations destabilize repeat tracts. Destabilization is evidenced both by the increased frequency of repeat length changes and in the pattern of changes that are...
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