Article
Allele-specific variation in the degeneracy of major histocompatibility complex (MHC) restriction.
Human immunology - 15 Apr 1997
Carmichael P, Copier J, So A, Lechler R
Abstract excerpt
The role of peptides in determining immune responses for both allorecognition and antigen-specific recognition has been clearly documented. The importance of different regions of the major histocompatibility complex (MHC) class II molecule in contributing to recognition has been demonstrated by studies involving site-directed mutagenesis and exon shuffling. These studies have indicated that the N-terminal region...
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