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Article

Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1997

Barber L D, Percival L, Arnett K L, Gumperz J E, Chen L, Parham P

Abstract excerpt

Previously, we reported overlap in the repertoires of peptides endogenously bound by a group of HLA-B allotypes related to HLA-B7. Extending such analysis to four members of the B17 family and seven members of the B15 family shows that allotypes that share sequence identity in the alpha 1 helix o...

Topics

Alleles
Amino Acid Sequence
Epitopes
Evolution, Molecular
HLA-B Antigens
Humans
Isoantigens
Molecular Sequence Data
Peptides
Polymorphism, Genetic
Protein Structure, Tertiary
Sequence Homology, Amino Acid

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PMID: 9029102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9029102-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity.PMID 9029102Read ↗

Several HLA alleles share overlapping peptide specificities.Semantic proximity Read ↗

Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.Semantic proximity Read ↗

Several common HLA-DR types share largely overlapping peptide binding repertoires.Semantic proximity Read ↗

HLA-B15: a widespread and diverse family of HLA-B alleles.Semantic proximity Read ↗

Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism.Semantic proximity Read ↗

The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.Semantic proximity Read ↗

Alpha-2 domain polymorphism and HLA class I peptide loading.Semantic proximity Read ↗

Non-conservative substitutions distinguish previously uncharacterized HLA-A molecules.Semantic proximity Read ↗

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Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?Semantic proximity Read ↗

Modulation of peptide binding by HLA-B27 polymorphism in pockets A and B, and peptide specificity of B*2703.Semantic proximity Read ↗

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.Semantic proximity Read ↗

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